Well I have suffered with depression since puberty, but was only on meds for a year or so and then did fine without it. With my drs recommendation I went back on ani depression meds for a few months after my first child and was fine when I went off of them. With my second child I was much more depressed and now I have been on meds ever since (over 3 years). I don't know exactly what changed, but now I have to be on the meds to stay level. My brain chemisty changed, it was weird.